The P-PERSoN (Prevention of Postperative Events following Reversal with Sugammadex or Neostigmine) Trial

A prospective, blinded, randomised controlled trial of 976 patients to determine if the use of sugammadex (compared with neostigmine) reduces the rate of postoperative pulmonary complications (PPCs).

Secondary outcomes will look at;

If the use of sugammadex improves patient quality of recovery
If the use of sugammadex reduces the rate of postoperative nausea and vomiting
If the use of sugammadex reduces the rate of airway complications in the PACU

Eligible patients will be;
>18 years old
presenting for non cardiac surgery and;
planned operative time of over 2 hours and;
plan to be intubated and to receive muscle relaxants during their anaesthetic and;
plan to stay at least one night in hospital

Exclusion criteria;
Previous recruitment to the trial
Patient refusal
Patient weight>200kg
Planned postoperative intubation and ventilation
Hypersensitivity reactions to any of the study drugs
Contraindications to study drugs

ANZCTR Trial number: ACTRN12616000063415 identifier (NCT number): NCT02825576

P-PERSON Trial Protocol

P-PERSON CRF Data Sheets